Vpx Association with Mature Core Structures of HIV-2
نویسندگان
چکیده
منابع مشابه
Analysis of HIV-2 Vpx by modeling and insertional mutagenesis.
Vpx facilitates HIV-2 nuclear localization by a poorly understood mechanism. We have compared Vpx to an NMR structure HIV-1 Vpr in a central helical domain and probed regions of Vpx by insertional mutagenesis. A predicted loop between helices two and three appears to be unique, overlapping with a known novel nuclear localization signal. Overall, Vpx was found to be surprisingly flexible, tolera...
متن کاملRole of poly-proline motif in HIV-2 Vpx expression
Human and simian immunodeficiency viruses (HIV and SIVs) contain several auxiliary genes not found in other retroviruses. These genes are thought to be functionally important for optimal viral replication and persistence in infected individuals. Primate lentiviruses can be classified by the composition of these accessory genes. While viruses of the HIV type1 (HIV-1) group have vif, vpr, vpu, an...
متن کاملSeparation and Recovery of Platinum by Magnetic Core-shell Nano-structures Modified with N-(2-aminoethyl)-3-aminopropyltrimethoxysilane
In this paper, Fe 3 O 4 @SiO 2 core/shell magnetic nanostructure has been synthesized and modified by N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (AEAPTMS). Fe 3 O 4 @SiO 2 was used as a novel adsorbent for separation of hexachloroplatinic acid.X-ray diffraction (XRD), scanning electron microscopy (SEM), and FT-IR technique were used to characterize morphologies and surface te...
متن کاملH11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1
Virus-host interactions play vital roles in viral replication and virus-induced pathogenesis. Viruses rely entirely upon host cells to reproduce progeny viruses; however, host factors positively or negatively regulate virus replication by interacting with viral proteins. The elucidation of virus-host protein interaction not only provides a better understanding of the molecular mechanisms by whi...
متن کاملSAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein
Both human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) encode a unique set of accessory proteins that enhance viral replication in the host. Two similar accessory proteins, Vpx and Vpr, are encoded by HIV-2. In contrast, HIV-1 encodes Vpr but not Vpx. Recent studies have indicated that Vpx counteracts a particular host restriction factor, thereby facilitating reverse tr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Virology
سال: 1996
ISSN: 0042-6822
DOI: 10.1006/viro.1996.0176